Medicare National Coverage Determinations (NCD) Manual (Pub. 100-03), Ch. 1 § 30.6
Intravenous Histamine Therapy
30.6 - Intravenous Histamine Therapy
(Rev. 1, 10-03-03)
CIM 35-19
The only accepted and scientifically valid medical use of histamine is diagnostic,
including tests to assess:
• The ability of the stomach to secrete acid;
• The integrity of peripheral sensory nerves (e.g., in leprosy);
• The circulatory competency in limb extremities; and
• The presence of a pheochromocytoma.
However, there is no scientifically valid clinical evidence that histamine therapy is
effective for any condition regardless of the method of administration, nor is it accepted
or widely used by the medical profession. Therefore, histamine therapy cannot be
considered reasonable and necessary, and program payment for such therapy is not made.