Medicare Claims Processing Manual (Pub. 100-04), Ch. 17 § 80.2.2
Claims Processing Jurisdiction for Oral Anti-Emetic Drugs
80.2.2 - Claims Processing Jurisdiction for Oral Anti-Emetic Drugs
(Rev. 2931, Issued: 04-15-14, Effective: 05-29-13, Implementation: 07-07-14)
The following chart shows which drugs are billed to the A/B MAC (A) or (B) and which drugs are
billed to the DME MAC.
Per the Balanced Budget Act of 1997, effective for claims with dates of service on or after January 1,
1998, the claims processing jurisdiction rules in Chart 1 apply. Effective July 1, 2006, claims from
institutional (hospital) pharmacies are also billed as shown in this chart.
CHART 1
COMBINATION
JURISDICTION
Oral anti-cancer
chemotherapy drug with oral
anti-emetic drug
DME MAC maintains processing responsibility for the
National Drug Code (NDC) oral anti-cancer
chemotherapy drug and the K0415 oral anti-emetic drug
code combinations.
DME MAC processes the NDC oral anti-cancer
chemotherapy drug and Q code oral anti-emetic drug(s)
when provided in the physician’s office.
A/B MAC (A) processes the 3-drug combination anti-
emetic (Aprepitant) in the form of a Tri-Pak when
dispensed by a hospital.
A/B MAC (A) processes the initial days’ supply of the 3-
drug anti-emetic combination when a hospital dispenses
it and writes a prescription for the second and third days’
supply.
DME MAC processes the second and third days’ supply
of the 3-drug anti-emetic combination.
DME MAC processes the NDC oral anti-cancer
chemotherapy drug and/or Q code oral anti-emetic
drug(s) when supplied by a pharmacy, including a
hospital pharmacy.
Oral anti-cancer
chemotherapy drug with
rectal anti-emetic drug
DME MAC maintains responsibility for processing both
the NDC oral anti-cancer chemotherapy drug and the
K0416 rectal anti-emetic drug.
Oral anti-cancer
chemotherapy drug with
intravenous anti-emetic drug
DME MAC maintains responsibility for processing the
NDC oral anti-cancer chemotherapy drug and the A/B
MAC (B) or A/B MAC (A) for processing the
intravenous anti-emetic J code drug(s).
Intravenous anti-cancer
chemotherapy drug with oral
anti-emetic drug
A/B MAC (B) processes the intravenous J code anti-
cancer chemotherapy drug. The oral anti-emetic Q code
drug(s) is processed by the DME MAC when provided in
the physician’s office, hospital, or when provided by a
supplier.
Intravenous anti-cancer
chemotherapy drug with
intravenous anti-emetic drug
A/B MAC (B) processes both intravenous anti-cancer
chemotherapy J code drug and intravenous anti-emetic J
code drug(s).
Providers (HIPAA definition) that bill the DME MAC require a supplier number issued by the National
Supplier Clearinghouse (NSC) in order to submit claims. A/B MACs (A) and (B) should instruct
providers without a supplier number to contact the NSC service center at 1-866-238-9652 to request an
enrollment package for a supplier number. Alternatively, providers may go to the CMS Web site,
http://www.cms.gov/Medicare/Provider-Enrollment-and-
Certification/MedicareProviderSupEnroll/EnrollmentApplications.html and download the Form CMS-
855-S in Adobe Acrobat format. The application can be completed hard copy and submitted to the
NSC.