Medicare Claims Processing Manual (Pub. 100-04), Ch. 17 § 80.9
Required Modifiers for ESAs Administered to Non-ESRD
80.9 - Required Modifiers for ESAs Administered to Non-ESRD
Patients
(Rev. 3721, Issued: 02-24-17, Effective: 05-25-17, Implementation: 05-25-17)
Effective January 1, 2008, all non-ESRD claims billing HCPCS J0881 and J0885 must
begin reporting one of the following modifiers:
EA: ESA, anemia, chemo-induced
EB: ESA, anemia, radio-induced
EC: ESA, anemia, non-chemo/radio
Institutional claims that do not report one of the above modifiers will be returned to the
provider.
Professional claims that are billed without the required modifiers will be returned as
unprocessable.
The contractor shall use the following remittance advice messages and associated codes
when rejecting/denying claims under this policy. This CARC/RARC combination is
compliant with CAQH CORE Business Scenario Two.
Group Code: CO
CARC: 4
RARC: N/A
MSN: N/A
ESAs administered for more than one of the indicated therapies are billed as separate line
items (i.e., ESAs for chemo-induced anemia (EA modifier) are reported as separate line
items (e.g., J0881EA); ESAs for radio-induced anemia (EB modifier) are reported as
separate line items (e.g., J0885EB); ESAs for non-chemo/radio induced anemia (EC
modifier) are reported as separate line items (e.g., J0881EC). Only one of the three ESA
modifiers may be reported at the line item level.
To return HCPCS J0881 or J0885 billed with more than one ESA modifier at the line
item level, the contractor shall use the following remittance advice messages and
associated codes when rejecting/denying claims under this policy. This CARC/RARC
combination is compliant with CAQH CORE Business Scenario Two.
Group Code: CO
CARC: 16
RARC: N63
MSN: N/A