Medicare Claims Processing Manual (Pub. 100-04), Ch. 24 § 40.1
Centers for Medicare and Medicaid Services - Medicare Fee-For-
40.1 - Centers for Medicare and Medicaid Services - Medicare Fee-For-
Service
(Rev. 13105; Issued- 04-10-25; Effective: 05-12-25; Implementation: 05-12-25)
A/B MACs, DME MACs along with the Common Electric Data Interchange (CEDI)
contractor must transact versions of the institutional and professional claim (ASC X12
837 claim, institutional, professional and dental), the remittance advice (ASC X12 835
remittance advice), the claim status request and response (ASC X12 276/277 claim status
request and response), the eligibility inquiry and response (ASC X12 270/271 eligibility),
and the newly adopted error handling transactions (the ASC X12 277 CA claim
acknowledgment, the ASC X12 999 implementation acknowledgment and the ASC X12
TA1 interchange acknowledgment) within national standards developed by ASC X12.
CEDI must transact versions of the National Council for Prescription Drug Programs
(NCPDP) claims transactions.
Medicare FFS supports EDI as exchanged between all covered entities and Medicare FFS
contractors. This chapter provides guidance on how these relationships and the
transactions generated by them shall be established, maintained and managed.