Medicare Claims Processing Manual (Pub. 100-04), Ch. 32 § 11.3.2
Healthcare Common Procedure Coding System (HCPCS) Codes and Diagnosis Coding
11.3.2 – Healthcare Common Procedure Coding System (HCPCS) Codes and Diagnosis Coding
(Rev. 11214, Issued: 01-20-22, Effective:04-13-21, Implementation: 01-03-22 Shared Systems Contractors, 02-
14-22 MACs)
Healthcare Common Procedure Coding System (HCPCS) Code
Effective for claims with dates of service on or after April 13, 2021, Medicare providers shall report HCPCS code
G0460 for PRP services for the treatment of chronic non-healing non-diabetic wounds.
Effective for claims with dates of service on or after April 13, 2021, Medicare providers shall report HCPCS code
G0465 for PRP services for the treatment of chronic non-healing diabetic wounds under the conditions and criteria
outlined in NCD Manual Section 270.3.
If ICD-10 Diagnosis coding is applicable
For claims with dates of service on or after April 13, 2021, PRP, for the treatment of chronic non-healing diabetic
wounds must be billed reporting both an ICD-10 diagnosis code for diabetes mellitus and an ICD-10 diagnosis code
for chronic ulcers.
- Two diagnosis codes are required- Diabetic Mellitus plus Chronic Ulcer
Diabetes Mellitus
E08.621
Diabetes mellitus due to underlying condition with foot ulcer
E08.622
Diabetes mellitus due to underlying condition with other skin ulcer
E09.621
Drug or chemical induced diabetes mellitus with foot ulcer
E09.622
Drug or chemical induced diabetes mellitus with other skin ulcer
E10.621
Type 1 diabetes mellitus with foot ulcer
E10.622
Type 1 diabetes mellitus with other skin ulcer
E11.621
Type 2 diabetes mellitus with foot ulcer
E11.622
Type 2 diabetes mellitus with other skin ulcer
E13.621
Other specified diabetes mellitus with foot ulcer
E13.622
Other specified diabetes mellitus with other skin ulcer
Chronic Ulcer
L97.111
Non-pressure chronic ulcer of right thigh limited to breakdown of skin
L97.112
Non-pressure chronic ulcer of right thigh with fat layer exposed
L97.113
Non-pressure chronic ulcer of right thigh with necrosis of muscle
L97.115
Non-pressure chronic ulcer of right thigh with muscle involvement without
evidence of
necrosis
L97.116
Non-pressure chronic ulcer of right thigh with bone involvement without evidence
of
necrosis
L97.118
Non-pressure chronic ulcer of right thigh with other specified severity
L97.114
Non-pressure chronic ulcer of right thigh with necrosis of bone
L97.121
Non-pressure chronic ulcer of left thigh limited to breakdown of skin
L97.122
Non-pressure chronic ulcer of left thigh with fat layer exposed
L97.123
Non-pressure chronic ulcer of left thigh with necrosis of muscle
L97.124
Non-pressure chronic ulcer of left thigh with necrosis of bone
L97.125
Non-pressure chronic ulcer of left thigh with muscle involvement without evidence
of necrosis
L97.126
Non-pressure chronic ulcer of left thigh with bone involvement without evidence of
necrosis
L97.128
Non-pressure chronic ulcer of left thigh with other specified severity
L97.211
Non-pressure chronic ulcer of right calf limited to breakdown of skin
L97.212
Non-pressure chronic ulcer of right calf with fat layer exposed
L97.213
Non-pressure chronic ulcer of right calf with necrosis of muscle
L97.214
Non-pressure chronic ulcer of right calf with necrosis of bone
L97.215
Non-pressure chronic ulcer of right calf with muscle involvement without evidence
of
necrosis
L97.216
Non-pressure chronic ulcer of right calf with bone involvement without evidence of
necrosis
L97.218
Non-pressure chronic ulcer of right calf with other specified severity
L97.221
Non-pressure chronic ulcer of left calf limited to breakdown of skin
L97.222
Non-pressure chronic ulcer of left calf with fat layer exposed
L97.223
Non-pressure chronic ulcer of left calf with necrosis of muscle
L97.224
Non-pressure chronic ulcer of left calf with necrosis of bone
L97.225
Non-pressure chronic ulcer of left calf with muscle involvement without evidence
of necrosis
L97.226
Non-pressure chronic ulcer of left calf with bone involvement without evidence of
necrosis
L97.228
Non-pressure chronic ulcer of left calf with other specified severity
L97.315
Non-pressure chronic ulcer of right ankle with muscle involvement without
evidence of necrosis
L97.316
Non-pressure chronic ulcer of right ankle with bone involvement without evidence
of necrosis
L97.318
Non-pressure chronic ulcer of right ankle with other specified severity
L97.321
Non-pressure chronic ulcer of left ankle limited to breakdown of skin
L97.322
Non-pressure chronic ulcer of left ankle with fat layer exposed
L97.323
Non-pressure chronic ulcer of left ankle with necrosis of muscle
L97.324
Non-pressure chronic ulcer of left ankle with necrosis of bone
L97.325
Non-pressure chronic ulcer of left ankle with muscle involvement without evidence
of necrosis
L97.326
Non-pressure chronic ulcer of left ankle with bone involvement without evidence of
necrosis
L97.328
Non-pressure chronic ulcer of left ankle with other specified severity
L97.411
Non-pressure chronic ulcer of right heel and midfoot limited to breakdown of skin
L97.412
Non-pressure chronic ulcer of right heel and midfoot with fat layer exposed
L97.413
Non-pressure chronic ulcer of right heel and midfoot with necrosis of muscle
L97.414
Non-pressure chronic ulcer of right heel and midfoot with necrosis of bone
L97.415
Non-pressure chronic ulcer of right heel and midfoot with muscle involvement
without evidence of necrosis
L97.416
Non-pressure chronic ulcer of right heel and midfoot with bone involvement
without evidence of necrosis
L97.418
Non-pressure chronic ulcer of right heel and midfoot with other specified severity
L97.421
Non-pressure chronic ulcer of left heel and midfoot limited to breakdown of skin
L97.422
Non-pressure chronic ulcer of left heel and midfoot with fat layer exposed
L97.423
Non-pressure chronic ulcer of left heel and midfoot with necrosis of muscle
L97.424
Non-pressure chronic ulcer of left heel and midfoot with necrosis of bone
L97.425
Non-pressure chronic ulcer of left heel and midfoot with muscle involvement
without evidence of necrosis
L97.426
Non-pressure chronic ulcer of left heel and midfoot with bone involvement
without evidence of necrosis
L97.428
Non-pressure chronic ulcer of left heel and midfoot with other specified severity
L98.411
Non-pressure chronic ulcer of buttock limited to breakdown of skin
L98.412
Non-pressure chronic ulcer of buttock with fat layer exposed
L98.413
Non-pressure chronic ulcer of buttock with necrosis of muscle
L98.414
Non-pressure chronic ulcer of buttock with necrosis of bone
L98.415
Non-pressure chronic ulcer of buttock with muscle involvement without evidence of
necrosis
L98.416
Non-pressure chronic ulcer of buttock with bone involvement without evidence of
necrosis
L98.418
Non-pressure chronic ulcer of buttock with other specified severity
L98.421
Non-pressure chronic ulcer of back limited to breakdown of skin
L98.422
Non-pressure chronic ulcer of back with fat layer exposed
L98.423
Non-pressure chronic ulcer of back with necrosis of muscle
L98.424
Non-pressure chronic ulcer of back with necrosis of bone
L98.425
Non-pressure chronic ulcer of back with muscle involvement without evidence of
necrosis
L98.426
Non-pressure chronic ulcer of back with bone involvement without evidence of
necrosis
L98.428
Non-pressure chronic ulcer of back with other specified severity
L98.491
Non-pressure chronic ulcer of skin of other sites limited to breakdown of skin
L98.492
Non-pressure chronic ulcer of skin of other sites with fat layer exposed
L98.493
Non-pressure chronic ulcer of skin of other sites with necrosis of muscle
L98.494
Non-pressure chronic ulcer of skin of other sites with necrosis of bone
Frequency Requirements:
Effective for claims with dates of service on and after April 13, 2021, contractors shall cover PRP services for chronic
non-healing diabetic wounds, G0465, for a maximum of 20 weeks beginning with the first week of treatment.
Effective for claims with dates of services on or after April 13, 2021, the local MACs shall have discretion to pay PRP
services for chronic non-healing diabetic wounds, G0465, that are performed more than 20 weeks after the date of the
first PRP service when the -KX modifier is reported on the claim.
Effective for claims with dates of service on and after April 13, 2021, contractors shall have discretion to cover, and
determine frequency for, PRP services for chronic non-healing non-diabetic wounds, G0460.