Medicare Claims Processing Manual (Pub. 100-04), Ch. 32 § 60
Coverage and Billing for Home Prothrombin Time (PT/INR) Monitoring for Home
60 – Coverage and Billing for Home Prothrombin Time (PT/INR) Monitoring for Home
Anticoagulation Management
(Rev. 1562, Issued: 07-25-08, Effective: 03-19-08, Implementation: 08-25-08)
The prothrombin time (PT) test is an in-vitro test to assess coagulation. PT testing and its normalized correlate, the
International Normalized Ratio (INR), are the standard measurements for therapeutic effectiveness of warfarin
therapy. Warfarin, Coumadin®, and others, are self-administered, oral anticoagulant, or blood thinner, medications
that affect a person’s Vitamin K-dependent clotting factors.
Use of the INR allows physicians to determine the level of anticoagulation in a patient independent of the laboratory
reagents used. The INR is the ratio of the patient's prothrombin time compared to the mean prothrombin time for a
group of normal individuals.