Medicare Claims Processing Manual (Pub. 100-04), Ch. 4 § 10.2.3
Comprehensive APCs
10.2.3 - Comprehensive APCs
(Rev. 12421; Issued: 12-21-23; Effective: 01-01-24; Implementation: 01-02-24)
The following services are excluded from comprehensive APC packaging:
• ambulance services
• brachytherapy sources (status indicator U)
• diagnostic and mammography screenings
• physical therapy, speech-language pathology and occupational therapy services reported
on a separate facility claim for recurring services
• pass-through drugs, biologicals, and devices (status indicators G or H)
• preventive services defined in 42 CFR 410.2
• self-administered drugs (SADs) - drugs that are usually self-administered and do not
function as supplies in the provision of the comprehensive service
• services assigned to OPPS status indicator F (including certain CRNA services,
Hepatitis B vaccines and corneal tissue acquisition)
• services assigned to OPPS status indicator L (including influenza, pneumococcal
pneumonia, and COVID-19 vaccines)
• certain Part B inpatient services – Ancillary Part B inpatient services payable under Part
B when the primary J1 service for the claim is not a payable Medicare Part B inpatient
service (for example, exhausted Medicare Part A benefits, beneficiaries with Part B only)
• services assigned to a New Technology APC
• Any drug or biological described by HCPCS code C9399 (Unclassified drugs or
biologicals)