Effective Dates

6006.6 – Effective Dates (Rev. 230; Issued: 07-11-25; Effective: 07-11-25; Implementation: 07-11-25) The effective date of the initial Certificate for PPM procedures, Certificate of Registration, or a Certificate of Waiver for new laboratories is the date the CLIA application, Form CMS-116 (Exhibit 125) is entered into the CLIA Data System. The effective date of the Certificate of Compliance is the date the laboratory is surveyed and found in compliance with the CLIA requirements. The effective date of the Certificate of Accreditation is the date the organization verifies to CMS that the laboratory is accredited. This date can be no earlier than the accreditation organization initial approval date. Once the effective dates are established, the laboratory’s 2-year certificate cycle is set.