Medicare Program Integrity Manual (Pub. 100-08), Ch. 4 § 4.2
The Medicare Program Integrity
4.2 - The Medicare Program Integrity
(Rev. 11032; Issued: 09-30-21; Effective: 10-12-21; Implementation: 11-10-21)
This section applies to UPICs, SMRCs and MACs, as indicated.
The primary goal of the UPIC is to identify cases of suspected fraud, waste and abuse,
develop them thoroughly and in a timely manner, and take immediate action to ensure
that Medicare Trust Fund monies are not inappropriately paid. Payment suspension and
denial of payments and the recoupment of overpayments are examples of the actions that
may be taken in cases of suspected fraud. Once such actions are taken, cases where there
is potential fraud are referred to LE for consideration and initiation of criminal or civil
prosecution, civil monetary penalties (CMP), or administrative sanction actions.
Preventing and detecting fraud, waste, and abuse involves a cooperative effort among
beneficiaries; UPICs; SMRCs; MACs; providers/suppliers; quality improvement
organizations (QIOs); and federal agencies such as CMS; the Department of Health and
Human Services (DHHS); the Office of Inspector General (OIG); the Federal Bureau of
Investigation (FBI); and the Department of Justice (DOJ).
Each investigation is unique and shall be tailored to the specific circumstances. These
guidelines are not to be interpreted as requiring the UPIC to follow a specific course of
action or establish any specific requirements on the part of the government or its agents
with respect to any investigation. Similarly, these guidelines shall not be interpreted as
creating any rights in favor of any person, including the subject of an investigation.
When the UPIC makes the determination of potential fraud, waste, and/or abuse, the
UPIC shall effectuate all appropriate administrative actions and refer the case to LE, if
appropriate. When the UPIC makes the determination that a matter is not potential fraud,
waste, and/or abuse, the UPIC shall close the matter, or de-escalate the matter to the
appropriate unit at the MAC, QIO, or other entity, when appropriate.