49 C.F.R. § 655.21
Drug testing.
Cite as 49 C.F.R. § 655.21 (2026)
(a) An employer shall establish a program that provides testing for prohibited drugs and drug metabolites in the following circumstances: pre-employment, post-accident, reasonable suspicion, random, and return to duty/follow-up.
(b) When administering a drug test, an employer shall ensure that the following drugs are tested for:
(1) Marijuana;
(2) Cocaine;
(3) Opioids;
(4) Amphetamines; and
(5) Phencyclidine.
(c) Consumption of these products is prohibited at all times.
[66 FR 42002, Aug. 9, 2001, as amended at 84 FR 16775, Apr. 23, 2019]