21 C.F.R. § 172.510
Natural flavoring substances and natural substances used in conjunction with flavors.
Cite as 21 C.F.R. § 172.510 (2026)
Natural flavoring substances and natural adjuvants may be safely used in food in accordance with the following conditions.
(a) They are used in the minimum quantity required to produce their intended physical or technical effect and in accordance with all the principles of good manufacturing practice.
(b) In the appropriate forms (plant parts, fluid and solid extracts, concentrates, absolutes, oils, gums, balsams, resins, oleoresins, waxes, and distillates) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, previously sanctioned for such use, or regulated in any section of this part.
Common name
Scientific name
Limitations
Aloe
Aloe perryi
Baker,
A. barbadensis
Mill.,
A. ferox
Mill., and hybrids of this sp. with
A. africana
Mill. and
A. spicata
Baker
Althea root and flowers
Althea officinalis
L
Amyris (West Indian sandalwood)
Amyris balsamifera
L
Angola weed
Roccella fuciformis
Ach
In alcoholic beverages only
Arnica flowers
Arnica montana
L.,
A. fulgens
Pursh,
A. sororia
Greene, or
A. cordifolia
Hooker
Do.
Artemisia (wormwood)
Artemisia
spp
Finished food thujone free
1
Artichoke leaves
Cynara scolymus
L
In alcoholic beverages only
Benzoin resin
Styrax benzoin
Dryander,
S. paralleloneurus
Perkins,
S. tonkinensis
(Pierre) Craib ex Hartwich, or other spp. of the Section
Anthostyrax
of the genus
Styrax
Blackberry bark
Rubus,
Section
Eubatus
Boldus (boldo) leaves
Peumus boldus
Mol
Do.
Boronia flowers
Boronia megastigma
Nees
Bryonia root
Bryonia alba
L., or
B. diocia
Jacq
Do.
Buchu leaves
Barosma betulina
Bartl. et Wendl.,
B. crenulata
(L.) Hook. or
B. serratifolia
Willd
Buckbean leaves
Menyanthes trifoliata
L
Do.
Cajeput
Melaleuca leucadendron
L. and other
Melaleuca
spp
Calumba root
Jateorhiza palmata
(Lam.) Miers
Do.
Camphor tree
Cinnamomum camphora
(L.) Nees et Eberm
Safrole free
Cascara sagrada
Rhamnus purshiana
DC
Cassie flowers
Acacia farnesiana
(L.) Willd
Castor oil
Ricinus communis
L
Catechu, black
Acacia catechu
Willd
Cedar, white (aborvitae), leaves and twigs
Thuja occidentalis
L
Finished food thujone free
1
Centuary
Centaurium umbellatum
Gilib
In alcoholic beverages only
Cherry pits
Prunus avium
L. or
P. cerasus
L
Not to exceed 25 p.p.m. prussic acid
Cherry-laurel leaves
Prunus laurocerasus
L
Do.
Chestnut leaves
Castanea dentata
(Marsh.) Borkh
Chirata
Swertia chirata
Buch.-Ham
In alcoholic beverages only
Cinchona, red, bark
Cinchona succirubra
Pav. or its hybrids
In beverages only; not more than 83 p.p.m. total cinchona alkaloids in finished beverage
Cinchona, yellow, bark
Cinchona ledgeriana
Moens,
C. calisaya
Wedd., or hybrids of these with other spp. of
Cinchona.
Do.
Copaiba
South American spp. of
Copaifera
L
Cork, oak
Quercus suber
L., or
Q. occidentalis
F. Gay
In alcoholic beverages only
Costmary
Chrysanthemum balsamita
L
Do.
Costus root
Saussurea lappa
Clarke
Cubeb
Piper cubeba
L. f
Currant, black, buds and leaves
Ribes nigrum
L
Damiana leaves
Turnera diffusa
Willd
Davana
Artemisia pallens
Wall
Dill, Indian
Anethum sowa
Roxb. (
Peucedanum graveolens
Benth et Hook.,
Anethum graveolens
L.)
Dittany (fraxinella) roots
Dictamnus albus
L
Do.
Dittany of Crete
Origanum dictamnus
L
Dragon's blood (dracorubin)
Daemonorops
spp
Elder tree leaves
Sambucus nigra
L
In alcoholic beverages only; not to exceed 25 p.p.m. prussic acid in the flavor
Elecampane rhizome and roots
Inula helenium
L
In alcoholic beverages only
Elemi
Canarium commune
L. or
C. luzonicum
Miq
Erigeron
Erigeron canadensis
L
Eucalyptus globulus leaves
Eucalyptus globulus
Labill
Fir (“pine”) needles and twigs
Abies sibirica
Ledeb.,
A. alba
Mill.,
A. sachalinesis
Masters or
A. mayriana
Miyabe et Kudo
Fir, balsam, needles and twigs
Abies balsamea
(L.) Mill
Galanga, greater
Alpinia galanga
Willd
Do.
Galbanum
Ferula galbaniflua
Boiss. et Buhse and other
Ferula
spp
Gambir (catechu, pale)
Uncaria gambir
Roxb
Genet flowers
Spartium junceum
L
Gentian rhizome and roots
Gentiana lutea
L
Gentian, stemless
Gentiana acaulis
L
Do.
Germander, chamaedrys
Teucrium chamaedrys
L
Do.
Germander, golden
Teucrium polium
L
Do.
Guaiac
Guaiacum officinale
L.,
G. santum
L.,
Bulnesia sarmienti
Lor
Guarana
Paullinia cupana
HBK
Haw, black, bark
Viburnum prunifolium
L
Hemlock needles and twigs
Tsuga canadensis
(L.) Carr. or
T. heterophylla
(Raf.) Sarg
Hyacinth flowers
Hyacinthus orientalis
L
Iceland moss
Cetraria islandica
Ach
Do.
Imperatoria
Peucedanum ostruthium
(L.). Koch (
Imperatoria ostruthium
L.)
Iva
Achillea moschata
Jacq
Do.
Labdanum
Cistus
spp
Lemon-verbena
Lippia citriodora
HBK
Do.
Linaloe wood
Bursera delpechiana
Poiss. and other
Bursera
spp
Linden leaves
Tillia
spp
Do.
Lovage
Levisticum officinale
Koch
Lungmoss (lungwort)
Sticta pulmonacea
Ach
Maidenhair fern
Adiantum capillus-veneris
L
Do.
Maple, mountain
Acer spicatum
Lam
Mimosa (black wattle) flowers
Acacia decurrens
Willd. var.
dealbata
Mullein flowers
Verbascum phlomoides
L. or
V. thapsiforme
Schrad
Do.
Myrrh
Commiphora molmol
Engl.,
C. abyssinica
(Berg) Engl., or other
Commiphora
spp
Myrtle leaves
Myrtus communis
L
Do.
Oak, English, wood
Quercus robur
L
Do.
Oak, white, chips
Quercus alba
L
Oak moss
Evernia prunastri
(L.) Ach.,
E. furfuracea
(L.) Mann, and other lichens
Finished food thujone free
1
Olibanum
Boswellia carteri
Birdw. and other
Boswellia
spp
Opopanax (bisabolmyrrh)
Opopanax chironium
Koch (true opopanax) of
Commiphora erythraea
Engl. var.
Llabrescens
Orris root
Iris germanica
L. (including its variety
florentina
Dykes) and
I. pallida
Lam
Pansy
Viola tricolor
L
In alcoholic beverages only
Passion flower
Passiflora incarnata
L
Patchouly
Pogostemon cablin
Benth. and
P. heyneanus
Benth
Peach leaves
Prunus persica
(L.) Batsch
In alcoholic beverages only; not to exceed 25 p.p.m. prussic acid in the flavor
Pennyroyal, American
Hedeoma pulegioides
(L.) Pers
Pennyroyal, European
Mentha pulegium
L
Pine, dwarf, needles and twigs
Pinus mugo
Turra var.
pumilio
(Haenke) Zenari
Pine, Scotch, needles and twigs
Pinus sylvestris
L
Pine, white, bark
Pinus strobus
L
In alcoholic beverages only
Pine, white oil
Pinus palustris
Mill., and other
Pinus
spp
Poplar buds
Populus balsamifera
L. (
P. tacamahacca
Mill.),
P. candicans
Ait., or
P. nigra
L
Do.
Quassia
Picrasma excelsa
(Sw.) Planch, or
Quassia amara
L
Quebracho bark
Aspidosperma quebracho-blanco
Schlecht, or (
Quebrachia lorentzii
(Griseb))
Schinopsis lorentzii
(Griseb.) Engl.
Quillaia (soapbark)
Quillaja saponaria
Mol
Red saunders (red sandalwood)
Pterocarpus san alinus
L
In alcoholic beverages only
Rhatany root
Krameria triandra
Ruiz et Pav. or
K. argentea
Mart
Rhubarb, garden root
Rheum rhaponticum
L
Do.
Rhubarb root
Rheum officinale
Baill.,
R. palmatum
L., or other spp. (excepting
R. rhaponticum
L.) or hybrids of
Rheum
grown in China
Roselle
Hibiscus sabdariffa
L
Do.
Rosin (colophony)
Pinus palustris
Mill., and other
Pinus
spp
Do.
St. Johnswort leaves, flowers, and caulis
Hypericum perforatum
L
Hypericin-free alcohol distillate form only; in alcoholic beverages only
Sandalwood, white (yellow, or East Indian)
Santalum album
L
Sandarac
Tetraclinis articulata
(Vahl.), Mast
In alcoholic beverages only
Sarsaparilla
Smilax aristolochiaefolia
Mill., (Mexican sarsaparilla),
S. regelii
Killip et Morton (Honduras sarsaparilla),
S. febrifuga
Kunth (Ecuadorean sarsaparilla), or undetermined
Smilax
spp. (Ecuadorean or Central American sarsaparilla)
Sassafras leaves
Sassafras albidum
(Nutt.) Nees
Safrole free
Senna, Alexandria
Cassia acutifolia
Delile
Serpentaria (Virginia snakeroot)
Aristolochia serpentaria
L
In alcoholic beverages only
Simaruba bark
Simaruba amara
Aubl
Do.
Snakeroot, Canadian (wild ginger)
Asarum canadense
L
Spruce needles and twigs
Picea glauca
(Moench) Voss or
P. mariana
(Mill.) BSP
Storax (styrax)
Liquidambar orientalis
Mill. or
L. styraciflua
L
Tagetes (marigold)
Tagetes patula
L.,
T. erecta
L., or
T. minuta
L. (
T. glandulifera
Schrank)
As oil only
Tansy
Tanacetum vulgare
L
In alcoholic beverages only; finished alcoholic beverage thujone free
1
Thistle, blessed (holy thistle)
Onicus benedictus
L
In alcoholic beverages only
Thymus capitatus
(Spanish “origanum”)
Thymus capitatus
Hoffmg. et Link
Tolu
Myroxylon balsamum
(L.) Harms
Turpentine
Pinus palustris
Mill. and other
Pinus
spp. which yield terpene oils exclusively
Valerian rhizome and roots
Valeriana officinalis
L
Veronica
Veronica officinalis
L
Do.
Vervain, European
Verbena officinalis
L
Do.
Vetiver
Vetiveria zizanioides
Stapf
Do.
Violet, Swiss
Viola calcarata
L
Walnut husks (hulls), leaves, and green nuts
Juglans nigra
L. or
J. regia
L
Woodruff, sweet
Asperula odorata
L
In alcoholic beverages only
Yarrow
Achillea millefolium
L
In beverages only; finished beverage thujone free
1
Yerba santa
Eriodictyon californicum
(Hook, et Arn.) Torr
Yucca, Joshua-tree
Yucca brevifolia
Engelm
Yucca, Mohave
Yucca schidigera
Roezl ex Ortgies (
Y. mohavensis
Sarg.)
1
As determined by using the method (or, in other than alcoholic beverages, a suitable adaptation thereof) in section 9.129 of the “Official Methods of Analysis of the Association of Official Analytical Chemists,” 13th Ed. (1980), which is incorporated by reference. Copies may be obtained from the AOAC INTERNATIONAL, 481 North Frederick Ave., suite 500, Gaithersburg, MD 20877, or may be examined at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, call 202-741-6030, or go to:
http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html.
[42 FR 14491, Mar. 15, 1977, as amended at 43 FR 14644, Apr. 7, 1978; 49 FR 10104, Mar. 19, 1984; 54 FR 24897, June 12, 1989; 69 FR 24511, May 4, 2004; 72 FR 10357, Mar. 8, 2007]