21 C.F.R. § 558.586
Sulfaquinoxaline.
Cite as 21 C.F.R. § 558.586 (2026)
(a)
Specifications.
Type A medicated articles containing 40 percent sulfaquinoxaline.
(b)
Sponsor.
See No. 016592 in § 510.600(c) of this chapter.
(c)
Related tolerances.
See § 556.685 of this chapter.
(d)
Special considerations.
(1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See § 558.6 for additional requirements.
(2) The expiration date of VFDs for sulfaquinoxaline medicated feeds must not exceed 6 months from the date of issuance. VFDs for sulfaquinoxaline shall not be refilled.
(e)
Conditions of use
—(1)
Chickens
—
Sulfaquinoxaline
in grams/ton
Combination in grams/ton
Indications for use
Limitations
Sponsor
(i) 0.015 percent
As an aid in preventing outbreaks of coccidiosis caused by
Eimeria tenella, E. necatrix,
E. acervulina, E. maxima,
and
E. brunetti
under average conditions of exposure
Feed continuously from the time birds are placed on litter and continue past the age when coccidiosis is ordinarily a hazard. If death losses exceed 0.5 percent in a 2-day period, obtain a laboratory diagnosis. If coccidiosis is the cause, use the sulfaquinoxaline levels recommended for control of outbreaks, returning to the original dosage schedule after the outbreak has subsided. Losses may result from intercurrent disease, other conditions affecting drug intake, or variant strains of coccidia species which can contribute to the virulence of coccidiosis under field conditions. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption
016592
(ii) 0.0175 percent
As an aid in preventing outbreaks of coccidiosis caused by
Eimeria tenella, E. necatrix,
E. acervulina, E. maxima,
and
E. brunetti
where excessive exposure to coccidia is increased due to overcrowding or other management factors
Feed continuously from the time birds are placed on litter and continue past the age when coccidiosis is ordinarily a hazard. If death losses exceed 0.5 percent in a 2-day period, obtain a laboratory diagnosis. If coccidiosis is the cause, use the sulfaquinoxaline levels recommended for control of outbreaks, returning to the original dosage schedule after the outbreak has subsided. Losses may result from intercurrent disease, other conditions affecting drug intake, or variant strains of coccidia species which can contribute to the virulence of coccidiosis under field conditions. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption
016592
(iii) 0.1 to 0.05 percent
As an aid in controlling outbreaks of coccidiosis caused by
Eimeria tenella, E. necatrix,
E. acervulina, E. maxima,
and
E. brunetti
Feed at 0.1 percent level for first 48 to 72 hours. Skip 3 days; 0.05 percent for 2 days, skip 3 days; 0.05 percent for 2 days. If bloody droppings recur, give 0.05 percent for another 2 days. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption
016592
(iv) 0.05 or 0.1 percent
As an aid in the control of acute fowl cholera caused by
Pasteurella multocida
susceptible to sulfaquinoxaline and fowl typhoid caused by
Salmonella gallinarum
susceptible to sulfaquinoxaline
Feed 0.1 percent for 48 to 72 hours. Mortality should be brought under control. After medication, move birds to clean ground or to a clean house. If disease recurs, use 0.05 percent in feed again for 2 days. Do not treat chickens or turkeys within 10 days of slaughter for food. Do not medicate chickens or turkeys producing eggs for human consumption
016592
(2)
Turkeys
—
Sulfaquinoxaline
in grams/ton
Combination in grams/ton
Indications for use
Limitations
Sponsor
(i) 0.0175 percent
As an aid in preventing outbreaks of coccidiosis caused by
Eimeria meleagrimitis
and
E. adenoeides
Feed continuously during time birds are closely confined. May be continued for a week to 10 days after flock is transferred to range to reduce danger of an outbreak following moving of the flock. Do not treat turkeys within 10 days of slaughter. Do not medicate turkeys producing eggs for human consumption
016592
(ii) 0.05 percent
As an aid in controlling outbreaks of coccidiosis caused by
Eimeria meleagrimitis
and
E. adenoeides
Feed for 2 days. Follow with 3 days on regular feed and 2 more days on 0.05 percent sulfaquinoxaline feed. Again follow with 3 days on regular feed and 2 more days on 0.05 percent sulfaquinoxaline feed. Continue this schedule if necessary until all signs of the outbreaks have subsided. Do not treat turkeys within 10 days of slaughter. Do not medicate turkeys producing eggs for human consumption
016592
(iii) 0.05 or 0.1 percent
As an aid in the control of acute fowl cholera caused by
Pasteurella multocida
susceptible to sulfaquinoxaline and fowl typhoid caused by
Salmonella gallinarum
susceptible to sulfaquinoxaline
Feed 0.1 percent for 48 to 72 hours. Mortality should be brought under control. After medication, move birds to clean ground or to a clean house. If disease recurs, use 0.05 percent in feed again for 2 days. Do not treat chickens or turkeys within 10 days of slaughter for food. Do not medicate chickens or turkeys producing eggs for human consumption
016592
(3)
Rabbits
—
Sulfaquinoxaline
in grams/ton
Combination in grams/ton
Indications for use
Limitations
Sponsor
(i) 0.025 percent
As an aid in preventing coccidiosis caused by
Eimeria stiedae
Treatment to be started after weaning. Feed continuously for 30 days or feed medicated feed for 2 days out of every week until marketing. Do not treat within 10 days of slaughter
016592
(ii) 0.1 percent
As an aid in controlling outbreaks of coccidiosis caused by
Eimeria stiedae
Feed for 2 weeks. Do not treat within 10 days of slaughter
016592
[81 FR 95013, Dec. 27, 2016]
- Cross-references to the CFR
- 510.600556.685558.6