105 CMR 721.070
ePrescribing Exceptions
(A) The following Prescriptions shall not be required to be issued as Electronic Prescriptions,
and may be issued as Written or Oral Prescriptions, provided, however, that Oral Prescriptions
must comply with 105 CMR 721.070(B) and that no Written or Oral Prescription may be issued
under any exception enumerated below in an effort to circumvent the requirement to issue an
Electronic Prescription:
(1) Prescriptions issued by veterinarians;
(2) Prescriptions issued or dispensed in circumstances where electronic prescribing is not
available due to temporary technological or electrical failure;
Prescriptions issued by practitioners who have applied for and received a waiver
pursuant to 105 CMR 721.075;
(4) Prescriptions issued or dispensed in Emergency Situations in accordance with 105 CMR
721.060;
(5) Prescriptions that cannot be issued electronically under federal or state law or
regulations, including those issued for a drug for which the U.S. Food and Drug
Administration (FDA) requires certain elements that cannot be accomplished with electronic
prescribing;
(6) Prescriptions issued outside the jurisdiction of the Commonwealth of Massachusetts;
(7) Prescriptions issued pursuant to 105 CMR 700.003(J) for expedited partner therapy for
treatment of chlamydia, which are intended for dispensing to the patient's partner;
Prescriptions for Compounded Drug Preparations, subject to standards outlined in
Department guidance;
(9) Prescriptions issued for controlled substances in schedule VI;
(10) Prescriptions for durable medical equipment, as defined in 42 U.S.C. § 1395x(n);
(11) Prescriptions issued prior to January 1, 2025, or such later date as determined by the
Department, to residents of Level I, II, or III Long-term Care Facilities, as defined in
105 CMR 150.000: Standards for Long-term Care Facilities; and
(12) Prescriptions issued in response to a declared public health emergency, pursuant to
M.G.L. c. 17, § 2A, or for the treatment, control and prevention of diseases dangerous to
public health, including sexually transmitted infections, pursuant to M.G.L. c. 111, § 6, or
for any other urgent public health matter.
(B) A practitioner issuing an Oral Prescription for a controlled substance in schedules II through
V, in accordance with 105 CMR 721.070(A), shall, within a period of not more than seven
business days, or such shorter period that is required by federal law, cause a Written or
Electronic Prescription for the prescribed controlled substance to be delivered to the dispensing
pharmacy. The Written Prescription may be delivered to the pharmacy in person or by mail, but
shall be postmarked within seven business days or such shorter period that is required by federal
law. The practitioner shall indicate on the Written Prescription that such Prescription is being
issued to document an Oral Prescription.
(C) A pharmacist who receives an otherwise valid Written or Oral Prescription is not required
to verify that such Prescription properly falls under one of the exceptions from the requirement
to electronically prescribe, including a waiver under 105 CMR 721.070(A)(3).
105 CMR - 4136.1