HEALTH RISK LIMITS TABLE

Subpart 1. Generally. This table lists the health risk limits derived from methods specified in parts 4717.7830 , 4717.7840 , and 4717.7850 . For each chemical, this table specifies: A. the chemical name; B. the CAS number; C. the year the HRL was adopted; D. the volatility classification; E. any noncancer HRL; F. any cancer HRL; G. the RfD and RSC used in the derivation of any noncancer HRL; H. the slope factor and any ADAF or AF lifetime used in the derivation of any cancer HRL; I. the intake rate used in the derivation of any noncancer or cancer HRL; and J. the health endpoints. Subp. 2. Explanation of table in this part. A. "--" symbol means not relevant. B. "NA" means not applicable. C. "ND" means not derived due to absence or paucity of toxicity information. D. "None" means not applicable for inclusion in the health risk index. E. The following explanations in subitems (1) to (3) apply where noted: (1) The acute HRL value is less than the calculated HRL. To be protective of acute exposures, the HRL is set equal to the acute HRL value. (2) The short-term HRL value is less than the calculated HRL. To be protective of short-term exposures, the HRL is set equal to the short-term HRL value. (3) The subchronic HRL value is less than the calculated HRL. To be protective of subchronic exposures, the HRL is set equal to the subchronic HRL value. Subp. 2a. Acenaphthene. CAS number: 83-32-9 Year Adopted: 2018 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 200 100 NA RfD (mg/kg-day) -- -- 0.070 0.021 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.070 0.044 -- Endpoints -- -- adrenal, hepatic (liver) system adrenal, hepatic (liver) system -- Subp. 2b. Acetaminophen. CAS number: 103-90-2 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 200 200 200 (2) 200 (2) NA RfD (mg/kg-day) 0.25 0.25 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 (2) (2) -- Endpoints hepatic (liver) system hepatic (liver) system hepatic (liver) system hepatic (liver) system -- Subp. 3. Acetochlor. CAS number: 34256-82-1 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 20 NA RfD (mg/kg-day) -- 0.016 0.012 0.0039 -- RSC -- 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 0.070 0.044 -- Endpoints -- developmental, hepatic (liver) system, thyroid (E) hepatic (liver) system, male reproductive system, nervous system, renal (kidney) system hepatic (liver) system, male reproductive system, nervous system, renal (kidney) system, respiratory system -- Subp. 3a. Acetochlor ESA. CAS number: 187022-11-3 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 500 500 300 NA RfD (mg/kg-day) -- 0.29 0.19 0.056 -- RSC -- 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 0.070 0.044 -- Endpoints -- thyroid (E) male reproductive system, thyroid (E) male reproductive system, thyroid (E) -- Subp. 3b. Acetochlor OXA. CAS number: 184992-44-4 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 100 (2) 90 NA RfD (mg/kg-day) -- 0.081 (2) 0.019 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) 0.044 -- Endpoints -- thyroid (E) thyroid (E) thyroid (E) -- Subp. 3c. Acetone. CAS number: 67-64-1 Year Adopted: 2023 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 5,000 5,000 (2) 3,000 NA RfD (mg/kg-day) -- 3.1 (2) 0.69 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) 0.045 -- Endpoints -- renal (kidney) system renal (kidney) system hematological (blood) system, hepatic (liver) system, renal (kidney) system -- Subp. 3d. 6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN). CAS number: 21145-77-7 or 1506-02-1 Year Adopted: 2013 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 30 20 NA RfD (mg/kg-day) -- 0.070 0.011 0.0037 -- RSC -- 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.289 0.077 0.043 -- Endpoints -- hepatic (liver) system hepatic (liver) system hepatic (liver) system -- Subp. 3e. Acrylamide. CAS number: 79-06-1 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 7 7 (2) 7 (2) 0.2 RfD (mg/kg-day) -- 0.010 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.5 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.289 (2) (2) 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints -- developmental, male reproductive system, nervous system developmental, male reproductive system, nervous system developmental, male reproductive system, nervous system cancer Subp. 4. Alachlor. CAS number: 15972-60-8 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 60 9 NA RfD (mg/kg-day) -- 0.077 0.020 0.0020 -- RSC -- 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 0.070 0.044 -- Endpoints -- developmental, renal (kidney) system hematological (blood) system, hepatic (liver) system, renal (kidney) system hematological (blood) system, hepatic (liver) system, renal (kidney) system -- Subp. 4a. Aminomethylphosphonic acid (AMPA). CAS number: 1066-51-9 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 3,000 1,000 -- RfD (mg/kg-day) -- -- 0.96 0.32 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.074 0.045 -- Endpoints -- -- hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system -- Subp. 5. Atrazine. CAS number: 1912-24-9 Year Adopted: 2009 Volatility: Nonvolatile MCL-based HRL: 3 µg/L Subp. 5a. Bentazon. CAS number: 25057-89-0 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 400 60 50 30 NA RfD (mg/kg-day) 0.22 0.033 0.020 0.0060 -- RSC 0.5 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 0.077 0.043 -- Endpoints developmental, female reproductive system developmental hematological (blood) system thyroid -- Subp. 6. Benzene. CAS number: 71-43-2 Year Adopted: 2009 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 10 10 3 3 (3) 2 RfD (mg/kg-day) 0.015 0.014 0.0013 (3) -- RSC 0.2 0.2 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- 0.055 ADAF -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate 0.289 0.289 0.077 (3) 0.137 (<2) (L/kg-day) 0.047 (2 to <16) 0.039 (16+) Endpoints develop- mental hemato- logical (blood) system, immune system hemato- logical (blood) system, immune system hemato- logical (blood) system, immune system cancer Subp. 6a. [Renumbered subp 6f] Subp. 6b. [Renumbered subp 6g] Subp. 6c. Benzo[a]pyrene. CAS number: 50-32-8 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.5 0.5 (2) 0.5 (2) 0.1 RfD (mg/kg-day) -- 0.00031 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 1 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.290 (2) (2) 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- developmental, nervous system developmental, nervous system developmental, nervous system cancer Subp. 6d. Benzophenone. CAS number: 119-61-9 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 900 100 100 (3) NA RfD (mg/kg-day) -- 0.52 0.053 (3) -- RSC -- 0.5 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 0.074 (3) -- Endpoints -- developmental hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system -- Subp. 6e. 1H-Benzotriazole. CAS number: 95-14-7 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 20 20 (2) 20 (2) NA RfD (mg/kg-day) -- 0.023 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 6f. Biphenyl. CAS number: 92-52-4 Year Adopted: 2023 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 400 100 100 (2) 100 (2) 10 RfD (mg/kg-day) 0.58 0.18 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.008 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) 0.290 0.290 (2) (2) 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints renal (kidney) system renal (kidney) system renal (kidney) system renal (kidney) system cancer Subp. 6g. Bisphenol A (BPA). CAS number: 80-05-7 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 20 20 (3) NA RfD (mg/kg-day) -- 0.16 0.0065 (3) -- RSC -- 0.2 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.289 0.077 (3) -- Endpoints -- developmental, female reproductive system (E), hepatic (liver) system, male reproductive system (E), renal (kidney) system, thyroid (E) hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system -- Subp. 6h. Bromodichloromethane. CAS number: 75-27-4 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 400 30 30 (2) 30 3 RfD (mg/kg-day) 0.073 0.039 (2) 0.0075 -- RSC 0.2 0.2 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.035 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) 0.038 0.290 (2) 0.045 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints female reproductive system (E) immune system, spleen immune system, spleen hepatic (liver) system cancer Subp. 6i. Butyl benzyl phthalate. CAS number: 85-68-7 Year Adopted: 2015 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 100 100 100 (2) 100 (2) NA RfD (mg/kg-day) 0.15 0.15 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 (2) (2) -- Endpoints developmental (E) developmental (E) developmental (E) developmental (E) -- Subp. 6j. Cadmium. CAS number: 7440-43-9 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 5 1 1 0.5 NA RfD (mg/kg-day) 0.0077 0.0016 0.00044 0.00011 -- RSC 0.2 0.2 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 0.077 0.043 -- Endpoints developmental developmental, nervous system, renal (kidney) system developmental, skeletal renal (kidney) system, skeletal -- Subp. 6k. Carbamazepine. CAS number: 298-46-4 Year Adopted: 2013 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 40 40 40 (2) 40 (2) NA RfD (mg/kg-day) 0.013 0.013 (2) (2) -- RSC 0.8 0.8 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate 0.289 0.289 (2) (2) -- (L/kg-day) Endpoints develop- mental, nervous system develop- mental, hematological (blood) system, hepatic (liver) system, immune system, nervous system, male reproductive system (E), female reproductive system (E), thyroid (E) develop- mental, hematological (blood) system, hepatic (liver) system, immune system, nervous system, male reproductive system (E), female reproductive system (E), thyroid (E) develop- mental, hematological (blood) system, hepatic (liver) system, immune system, nervous system, male reproductive system (E), female reproductive system (E), thyroid (E) -- Subp. 6l. Carbon tetrachloride. CAS number: 56-23-5 Year Adopted: 2013 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 100 3 3 (2) 3 (2) 1 RfD (mg/kg-day) 0.18 0.0037 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.07 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) 0.289 0.289 (2) (2) 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints develop- mental, hepatic (liver) system hepatic (liver) system hepatic (liver) system hepatic (liver) system cancer Subp. 7. Chloroform. CAS number: 67-66-3 Year Adopted: 2018 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 20 20 (2) 20 (2) NA RfD (mg/kg-day) -- 0.022 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system -- Subp. 7a. [Renumbered subp 7c] Subp. 7b. Chlorothalonil. CAS number: 1897-45-6 Year Adopted: 2025 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 20 2 1 6 RfD (mg/kg-day) -- 0.014 0.00067 0.00029 -- RSC -- 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.017 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.290 0.074 0.045 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- gastrointestinal system gastrointestinal system gastro- intestinal system, hepatic (liver) system, renal (kidney) system cancer Subp. 7c. Clothianidin. CAS number: 210880-92-5, 205510-53-8 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 200 200 (2) 200 (2) NA RfD (mg/kg-day) -- 0.093 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 7d. Cyanazine. CAS number: 21725-46-2 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 3 3 3 1 NA RfD (mg/kg-day) 0.0015 0.0015 0.0012 0.00022 -- RSC 0.5 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.285 0.285 0.070 0.044 -- Endpoints developmental, female reproductive system developmental, female reproductive system developmental, female reproductive system, hepatic (liver) system, renal (kidney) system None -- Subp. 7e. 1,2-Dibromoethane (EDB). CAS number: 106-93-4 Year Adopted: 2025 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 10 10 (2) 9 0.03 RfD (mg/kg-day) -- 0.018 (2) 0.0021 -- RSC -- 0.2 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- 3.6 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.290 (2) 0.045 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- female reproductive system, hepatic (liver) system, immune system, male reproductive system, renal (kidney) system, respiratory system, spleen female reproductive system, hepatic (liver) system, immune system, male reproductive system, renal (kidney) system, respiratory system, spleen female reproductive system, hepatic (liver) system, immune system, male reproductive system, respiratory system cancer Subp. 8. [Renumbered subp 7d] Subp. 8a. [Renumbered subp 8f] Subp. 8b. [Renumbered subp 8g] Subp. 8c. [Renumbered subp 8h] Subp. 8d. [Renumbered subp 8i] Subp. 8e. Dibutyl phthalate. CAS number: 84-74-2 Year Adopted: 2015 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 20 20 20 (2) 20 (2) NA RfD (mg/kg-day) 0.023 0.023 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 (2) (2) -- Endpoints developmental (E) developmental (E) developmental (E) developmental (E) -- Subp. 8f. 1, 4-Dichlorobenzene. CAS number: 106-46-7 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 50 50 (2) 50 (2) NA RfD (mg/kg-day) -- 0.069 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental, hepatic (liver) system, nervous system developmental, hepatic (liver) system, nervous system developmental, hepatic (liver) system, nervous system -- Subp. 8g. [Repealed, 50 SR 101] Subp. 8h. 1,2-Dichloroethane. CAS number: 107-06-2 Year Adopted: 2013 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 200 200 (2) 60 1 RfD (mg/kg-day) -- 0.23 (2) 0.012 -- RSC -- 0.2 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.091 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.289 (2) 0.043 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints -- hepatic (liver) system hepatic (liver) system renal (kidney) system, hepatic (liver) system cancer Subp. 8i. trans-1,2-Dichloroethene. CAS number: 156-60-5 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 50 9 NA RfD (mg/kg-day) -- -- 0.020 0.0020 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.074 0.045 -- Endpoints -- -- immune system immune system -- Subp. 8j. 1,1-Dichloroethylene (Vinylidene chloride). CAS number: 75-35-4 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 200 200 NA RfD (mg/kg-day) -- -- 0.069 0.040 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.074 0.045 -- Endpoints -- -- hepatic (liver) system hepatic (liver) system -- Subp. 8k. 1, 2-Dichloropropane. CAS number: 78-87-5 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 20 20 (2) 20 (2) 3 RfD (mg/kg-day) -- 0.029 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.037 ADAF or AF lifetime -- -- -- -- 10 (ADAF< 2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.290 (2) (2) 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- developmental developmental developmental cancer Subp. 9. cis 1,2-Dichloroethylene. CAS number: 156-59-2 Year Adopted: 2018 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 20 10 6 NA RfD (mg/kg-day) -- 0.033 0.0043 0.0013 -- RSC -- 0.2 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 0.070 0.044 -- Endpoints -- hepatic (liver) system renal (kidney) system renal (kidney) system -- Subp. 10. Dichloromethane. CAS number: 75-09-2 Year Adopted: 2009 Volatility: High MCL-based HRL: 5 µg/L Subp. 10a. 2,4-Dichlorophenoxyacetic acid (2,4-D). CAS number: 94-75-7 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 (2) 30 (2) NA RfD (mg/kg-day) -- 0.048 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- adrenal, developmental, thyroid (E) adrenal, developmental, thyroid (E) adrenal, developmental, thyroid (E) -- Subp. 11. Dieldrin. CAS number: 60-57-1 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.2 0.2 (2) 0.2 0.006 RfD (mg/kg-day) -- 0.00011 (2) 0.000043 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- 16 AF lifetime -- -- -- -- 2.5 Intake Rate (L/kg-day) -- 0.285 (2) 0.044 0.044 Endpoints -- developmental, immune system, nervous system developmental, immune system, nervous system developmental, hepatic (liver) system, immune system, nervous system cancer Subp. 11a. [Renumbered subp 11d] Subp. 11b. [Renumbered subp 11f] Subp. 11c. Di(2-ethylhexyl) phthalate (DEHP). CAS number: 117-81-7 Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 20 20 20 (2) 20 (2) 7 RfD (mg/kg-day) 0.029 0.029 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.014 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) 0.289 0.289 (2) (2) 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints develop- mental (E), male reproductive system (E) develop- mental (E), male reproductive system (E) develop- mental (E), male reproductive system (E) develop- mental (E), male reproductive system (E) cancer Subp. 11d. N,N-Diethyl-meta-toluamide (DEET). CAS number: 134-62-3 Year Adopted: 2013 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 200 200 (2) 200 (2) NA RfD (mg/kg-day) -- 0.23 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.289 (2) (2) -- Endpoints -- developmental, nervous system developmental, nervous system developmental, nervous system -- Subp. 11e. Dimethenamid and Dimethenamid-p. CAS numbers: 87674-68-8 and 163515-14-8 Year Adopted: 2015 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 600 600 (2) 300 NA RfD (mg/kg-day) -- 0.34 (2) 0.060 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.289 (2) 0.043 -- Endpoints -- developmental, female reproductive system, hepatic (liver) system, nervous system developmental, female reproductive system, hepatic (liver) system, nervous system hepatic (liver) system -- Subp. 11f. Dinoseb. CAS number: 88-85-7 Year Adopted: 2018 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 8 8 (2) 8 (2) NA RfD (mg/kg-day) -- 0.0048 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 11g. 1,4-Dioxane. CAS number: 123-91-1 Year Adopted: 2013 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 300 100 1 RfD (mg/kg-day) -- -- 0.12 0.025 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.1 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate -- -- 0.077 0.043 0.137 (<2) (L/kg-day) 0.047 (2 to <16) 0.039 (16+) Endpoints -- -- hepatic (liver) system, renal (kidney) system, respiratory system hepatic (liver) system, renal (kidney) system, respiratory system cancer Subp. 12. [Repealed, 40 SR 689] Subp. 12a. 17α-Ethinylestradiol. CAS number: 57-63-6 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.0005 0.0002 0.0002 NA RfD (mg/kg-day) -- 1.7 x 10 -7 1.4 x 10 -8 1.4 x 10 -8 -- RSC -- 0.8 0.8 0.8 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 0.074 0.045 -- Endpoints -- developmental (E), female reproductive system (E), male reproductive system (E) developmental developmental -- Subp. 12b. Ethylbenzene. CAS number: 100-41-4 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 40 40 (2) 40 (2) NA RfD (mg/kg-day) -- 0.06 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system -- Subp. 12c. S -Ethyl- N,N -dipropylthiocarbamate (EPTC). CAS number: 759-94-4 Year Adopted: 2018 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 300 300 90 40 NA RfD (mg/kg-day) 0.16 0.16 0.033 0.0083 -- RSC 0.5 0.5 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.285 0.285 0.070 0.044 -- Endpoints nervous system developmental, female reproductive system, nervous system cardiovascular system cardiovascular system -- Subp. 12d. Ethylene glycol. CAS number: 107-21-1 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 2,000 2,000 2,000 NA RfD (mg/kg-day) -- 0.33 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.038 (2) (2) -- Endpoints -- developmental developmental, renal (kidney) system developmental, male reproductive system, renal (kidney) system -- Subp. 12e. Fluoranthene. CAS number: 206-44-0 Year Adopted: 2018 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 200 70 NA RfD (mg/kg-day) -- -- 0.053 0.016 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.070 0.044 -- Endpoints -- -- hepatic (liver) system, renal (kidney) system hepatic (liver) system, renal (kidney) system -- Subp. 12f. Fluorene (9H-Fluorene). CAS number: 86-73-7 Year Adopted: 2023 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 200 80 NA RfD (mg/kg-day) -- -- 0.058 0.018 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.074 0.045 -- Endpoints -- -- hematological (blood) system, spleen hematological (blood) system, spleen -- Subp. 12g. Fomesafen. CAS number: 72178-02-0 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 200 200 (2) 20 NA RfD (mg/kg-day) -- 0.12 (2) 0.005 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) 0.045 -- Endpoints -- developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system hepatic (liver) system -- Subp. 12h. Imidacloprid. CAS number: 138261-41-3 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 100 2 2 (2) 2 (2) NA RfD (mg/kg-day) 0.15 0.0036 (2) (2) -- RSC 0.2 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.290 0.290 (2) (2) -- Endpoints nervous system immune system immune system immune system -- Subp. 12i. Manganese. CAS number: 7439-96-5 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 ND ND NA RfD (mg/kg-day) -- 0.083 -- -- -- RSC -- 0.5 -- -- -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 -- -- -- Endpoints -- developmental, nervous system -- -- -- Subp. 12j. Metolachlor and S-Metolachlor. CAS number: 51218-45-2; 87392-12-9 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 300 300 (2) 300 (2) NA RfD (mg/kg-day) -- 0.19 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 12k. Metolachlor ESA. CAS number: 171118-09-5 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 7,000 1,000 NA RfD (mg/kg-day) -- -- 2.7 0.27 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.074 0.045 -- Endpoints -- -- hepatic (liver) system hepatic (liver) system -- Subp. 12l. Metolachlor OXA. CAS number: 152019-73-3 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 5,000 5,000 (2) 1,000 NA RfD (mg/kg-day) -- 2.7 (2) 0.27 -- RSC -- 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) 0.045 -- Endpoints -- none none none -- Subp. 12m. Metribuzin. CAS number: 21087-64-9 Year Adopted: 2013 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 30 10 10 (2) 10 (2) NA RfD (mg/kg-day) 0.016 0.006 (2) (2) -- RSC 0.5 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 (2) (2) -- Endpoints developmental, nervous system thyroid (E) thyroid (E) thyroid (E) -- Subp. 12n. Naphthalene. CAS number: 91-20-3 Year Adopted: 2013 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 70 70 70 (2) 70 NA RfD (mg/kg-day) 0.038 0.038 (2) 0.016 -- RSC 0.5 0.5 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.289 0.289 (2) 0.043 -- Endpoints nervous system nervous system nervous system nervous system, spleen -- Subp. 13. Nitrate (as N). CAS number: 14797-55-8 Year Adopted: 2009 Volatility: Nonvolatile MCL-based HRL: 10,000 µg/L Subp. 13a. p-Nonylphenol (4-Nonylphenol). CAS number: 84852-15-3 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 40 20 NA RfD (mg/kg-day) -- 0.21 0.016 0.0049 -- RSC -- 0.2 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 0.074 0.045 -- Endpoints -- developmental, female reproductive system renal (kidney) system renal (kidney) system -- Subp. 13b. 4- tert -Octylphenol. CAS number: 140-66-9 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 100 (2) 100 (2) NA RfD (mg/kg-day) -- 0.17 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 14. Pentachlorophenol (PCP). CAS number: 87-86-5 Year Adopted: 2015 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 7 7 7 (2) 7 (2) 0.3 RfD (mg/kg-day) 0.0040 0.0040 (2) (2) -- RSC 0.5 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 0.4 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) 0.289 0.289 (2) (2) 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints develop- mental, thyroid (E) develop- mental (E), thyroid (E) develop- mental (E), hepatic (liver) system, immune system, male reproductive system, thyroid (E) develop- mental (E), hepatic (liver) system, immune system, male reproductive system, thyroid (E) cancer Subp. 14a. Perfluorobutane sulfonate (PFBS). CAS number: 45187-15-3; 375-73-5; 29420-49-3; 68259-10-9; 60453-92-1 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.1 0.1 (2) 0.1 (2) NA RfD (mg/kg-day) -- 0.000084 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- thyroid (E) thyroid (E) thyroid (E) -- Subp. 14b. Perfluorobutanoate (PFBA). CAS number: 45048-62-2; 375-22-4 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 7 7 (2) 7 (2) NA RfD (mg/kg-day) -- 0.0038 (2) (2) -- RSC -- 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- hepatic (liver) system, thyroid (E) hepatic (liver) system, thyroid (E) hepatic (liver) system, thyroid (E) -- Subp. 14c. Perfluorohexane sulfonate (PFHxS) and salts. CAS number: 108427-53-8; 355-46-4; 3871-99-6 Year Adopted: 2023 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) NA 0.047 0.047 0.047 NA RfD (mg/kg-day) -- 0.0000097 0.0000097 0.0000097 -- RSC -- 0.5 -- -- -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- * * * -- Endpoints -- hepatic (liver) system, thyroid (E) hepatic (liver) system, thyroid (E) hepatic (liver) system, thyroid (E) -- * 95th percentile water intake rates (Tables 3-1, 3-3, and 3-5 Environmental Protection Agency, Exposure Factors Handbook, 2019) or upper percentile breast milk intake rates (Table 15-1, Environmental Protection Agency, Exposure Factors Handbook, 2011), and MDH background information. Subp. 14d. Perfluorohexanoate (PFHxA) and salts. CAS number: 92912-52-7; 307-24-4; 21615-47-4; 2923-26-4 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.2 0.2 (2) 0.2 (2) NA RfD (mg/kg-day) -- 0.00032 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental, thyroid (E) developmental, thyroid (E) developmental, thyroid (E) -- Subp. 15. Perfluorooctane sulfonate (PFOS) and salts. CAS number: 45298-90-6; 1763-23-1; 29081-56-9; 2795-39-3; 70225-14-8; and 29457-72-5 Year Adopted: 2025 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.0023 0.0023 0.0023 0.0076 RfSC (ng/mL)* -- 2.6 2.6 2.6 -- RSC -- 0.2 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- 13 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- # # # 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system cancer * A reference serum concentration (ng/mL) rather than a reference dose (mg/kg-d) was used in MDH's toxicokinetic model to calculate noncancer guidance values for PFOS. # 95th percentile water intake rates (Tables 3-1, 3-3, and 3-5 in the Environmental Protection Agency, Exposure Factors Handbook, 2019), or upper percentile breast milk intake rates (Table 15-1), Environmental Protection Agency Exposure Factors Handbook, 2011. Subp. 16. Perfluorooctanoate (PFOA) and salts. CAS number: 45285-51-6; 335-67-1; 3825-26-1; 2395-00-8; 335-93-3; and 335-95-5 Year Adopted: 2025 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.00024 0.00024 0.00024 0.0000079 RfSC (ng/mL)* -- 0.93 0.93 0.93 -- RSC -- 0.2 0.2 0.2 -- SF (per ng/kg-day) -- -- -- -- 0.0126 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- # # # 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system developmental, hepatic (liver) system, immune system cancer * A reference serum concentration (ng/mL) rather than a reference dose (mg/kg-d) was used in MDH's toxicokinetic model to calculate noncancer guidance values for PFOA. # 95th percentile water intake rates (Tables 3-1, 3-3, and 3-5 in the Environmental Protection Agency, Exposure Factors Handbook, 2019), or upper percentile breast milk intake rates (Table 15-1), Environmental Protection Agency Exposure Factors Handbook, 2011. Subp. 16a. Pyrene. CAS number: 129-00-0 Year Adopted: 2018 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 90 50 NA RfD (mg/kg-day) -- -- 0.033 0.010 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.070 0.044 -- Endpoints -- -- renal (kidney) system renal (kidney) system -- Subp. 16b. Quinoline. CAS number: 91-22-5 Year Adopted: 2023 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND ND 4 0.03 RfD (mg/kg-day) -- -- -- 0.00079 -- RSC -- -- -- 0.2 -- SF (per mg/kg-day) -- -- -- -- 3 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate -- -- -- 0.045 0.155 (<2) (L/kg-day) 0.040 (2 to <16) 0.042 (16+) Endpoints -- -- -- hematological (blood) system, hepatic (liver) system, renal (kidney) system, respiratory system, and spleen cancer Subp. 17. Simazine. CAS number: 122-34-9 Year Adopted: 2009 Volatility: Nonvolatile MCL-based HRL: 4 µg/L Subp. 17a. Sulfamethazine (includes sodium salt form). CAS number: 57-68-1 (1981-58-4) Year Adopted: 2015 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 100 (2) 100 (2) NA RfD (mg/kg-day) -- 0.040 (2) (2) -- RSC -- 0.8 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.289 (2) (2) -- Endpoints -- thyroid thyroid thyroid -- Subp. 18. Tetrachloroethylene (PCE or PERC). CAS number: 127-18-4 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 7 7 (3) 4 RfD (mg/kg-day) -- -- 0.0026 (3) -- RSC -- -- 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- 0.0249 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- -- 0.074 (3) 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- -- nervous system nervous system cancer Subp. 18a. Tetrahydrofuran. CAS number: 109-99-9 Year Adopted: 2018 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 600 600 (2) 600 (2) NA RfD (mg/kg-day) -- 0.82 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 (2) (2) -- Endpoints -- developmental developmental developmental -- Subp. 18b. Thiamethoxam. CAS number: 153719-23-4 Year Adopted: 2018 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 400 200 200 (3) NA RfD (mg/kg-day) -- 0.25 0.057 (3) -- RSC -- 0.5 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.285 0.070 (3) -- Endpoints -- developmental, female reproductive system, hepatic (liver) system male reproductive system male reproductive system -- Subp. 18c. Toluene. CAS number: 108-88-3 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 70 70 (2) 70 (2) NA RfD (mg/kg-day) -- 0.10 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- immune system, nervous system immune system, nervous system immune system, nervous system -- Subp. 18d. 1,2,4-Trichlorobenezene. CAS number: 120-82-1 Year Adopted: 2013 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 100 100 (2) 100 4 RfD (mg/kg-day) -- 0.17 (2) 0.021 -- RSC -- 0.2 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.029 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate -- 0.289 (2) 0.043 0.137 (<2) (L/kg-day) 0.047 (2 to <16) 0.039 (16+) Endpoints -- hepatic (liver) system, adrenal (E), hemato- logical (blood) system hepatic (liver) system, adrenal (E), hemato- logical (blood) system hepatic (liver) system, adrenal (E), renal (kidney) system cancer Subp. 19. 1,1,1-Trichloroethane. CAS number: 71-55-6 Year Adopted: 2018 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 9,000 5,000 NA RfD (mg/kg-day) -- -- 3.0 1.0 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- -- 0.070 0.044 -- Endpoints -- -- hepatic (liver) system, male reproductive system hepatic (liver) system, male reproductive system -- Subp. 20. 1,1,2-Trichloroethylene (TCE). CAS number: 79-01-6 Year Adopted: 2015 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 0.4 0.4 0.4 (3) 2 RfD (mg/kg-day) -- 0.00052 0.00017 (3) -- RSC -- 0.2 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- 0.05 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- 0.289 0.077 (3) 0.137 (<2) 0.047 (2 to <16) 0.039 (16+) Endpoints -- develop- mental, immune system develop- mental, immune system develop- mental, immune system cancer Subp. 21. 2(2,4,5-Trichlorophenoxy)propionic acid (2,4,5-TP or Silvex). CAS number: 93-72-1 Year Adopted: 2009 Volatility: Nonvolatile MCL-based HRL: 50 µg/L Subp. 21a. 1,2,3-Trichloropropane. CAS number: 96-18-4 Year Adopted: 2013 Volatility: Moderate Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 7 7 7 (2) 7 (2) 0.003 RfD (mg/kg-day) 0.0042 0.0042 (2) (2) -- RSC 0.5 0.5 (2) (2) -- SF (per mg/kg-day) -- -- -- -- 30 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate 0.289 0.289 (2) (2) 0.137 (<2) (L/kg-day) 0.047 (2 to <16) 0.039 (16+) Endpoints develop- mental develop- mental develop- mental develop- mental cancer Subp. 21b. 1,2,3-Trimethylbenzene. CAS number: 526-73-8 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 (2) 30 (2) NA RfD (mg/kg-day) -- 0.042 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- nervous system nervous system nervous system -- Subp. 21c. 1,2,4-Trimethylbenzene. CAS number: 95-63-6 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 (2) 30 (2) NA RfD (mg/kg-day) -- 0.042 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- nervous system nervous system nervous system -- Subp. 22. 1,3,5-Trimethylbenzene. CAS number: 108-67-8 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 (2) 30 (2) NA RfD (mg/kg-day) -- 0.042 (2) (2) -- RSC -- 0.2 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- nervous system nervous system nervous system -- Subp. 22a. Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) CAS number: 13674-87-8 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 20 8 0.8 RfD (mg/kg-day) -- -- 0.0067 0.0019 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- 0.13 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate (L/kg-day) -- -- 0.074 0.045 0.155 (<2) 0.040 (2 to <16) 0.042 (16+) Endpoints -- -- hepatic (liver) system; kidney system male reproductive system; renal (kidney) system cancer Subp. 22b. Tris(2-butoxyethyl) phosphate (TBEP) CAS number: 78-51-3 Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 30 30 (2) 30 NA RfD (mg/kg-day) -- 0.043 (2) 0.0074 -- RSC -- 0.2 (2) 0.2 -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) 0.045 -- Endpoints -- hepatic (liver) system hepatic (liver) system hepatic (liver) system -- Subp. 22c. Tris(2-chloroethyl) phosphate. CAS number: 115-96-8 Year Adopted: 2013 Volatility: Low Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 300 200 200 (3) 5 RfD (mg/kg-day) -- 0.15 0.068 (3) -- RSC -- 0.5 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- 0.02 ADAF or AF lifetime -- -- -- -- 10 (ADAF <2 ) 3 (ADAF 2 to <16 ) 1 (ADAF 16+ ) Intake Rate -- 0.289 0.077 (3) 0.137 (<2) (L/kg-day) 0.047 (2 to <16) 0.039 (16+) Endpoints -- renal (kidney) system, nervous system, develop- mental renal (kidney) system renal (kidney) system cancer Subp. 22d. Venlafaxine. CAS number: 93413-69-5 (free base), 93300-78-4 (HCl salt) Year Adopted: 2023 Volatility: Nonvolatile Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND 10 10 (2) 10 (2) NA RfD (mg/kg-day) -- 0.0054 (2) (2) -- RSC -- 0.8 (2) (2) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) -- 0.290 (2) (2) -- Endpoints -- developmental, gastrointestinal system, male reproductive system, nervous system (E) developmental, gastrointestinal system, male reproductive system, nervous system (E) developmental, gastrointestinal system, male reproductive system, nervous system (E) -- Subp. 23. Vinyl Chloride. CAS number: 75-01-4 Year Adopted: 2018 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) ND ND 90 10 0.2 RfD (mg/kg-day) -- -- 0.033 0.0030 -- RSC -- -- 0.2 0.2 -- SF (per mg/kg-day) -- -- -- -- 1.4 AF lifetime -- -- -- -- 1 Intake Rate (L/kg-day) -- -- 0.070 0.044 0.044 Endpoints -- -- hepatic (liver) system hepatic (liver) system cancer Subp. 23a. Xylenes. CAS number: 1330-20-7 Year Adopted: 2023 Volatility: High Acute Short-term Subchronic Chronic Cancer HRL (µg/L) 700 300 300 300 (3) NA RfD (mg/kg-day) 1.0 0.38 0.12 (3) -- RSC 0.2 0.2 0.2 (3) -- SF (per mg/kg-day) -- -- -- -- -- ADAF or AF lifetime -- -- -- -- -- Intake Rate (L/kg-day) 0.290 0.290 0.074 (3) -- Endpoints nervous system developmental, nervous system developmental, renal (kidney) system, nervous system developmental, renal (kidney) system, nervous system -- Subp. 24. Transition. The health risk limits established for the specific chemicals in this part supersede the health risk limits for those chemicals in part 4717.7500 . For chemicals not included in this part, the health risk limits established in part 4717.7500 remain in place.