S.D. Codified Laws § 32-41-9
Operation of commercial vehicles
A fully autonomous vehicle that is also a commercial motor vehicle as defined in § 32-9-1 may operate pursuant to state laws governing the operation of commercial motor vehicles, except that any provision that reasonably applies only to a human driver does not apply to a vehicle operating with the automated driving system engaged.
Source: SL 2024, ch 122, § 9.