Medicare Claims Processing Manual (Pub. 100-04), Ch. 18 § 60.2.2
Ambulatory Surgical Center (ASC) Facility Fee
60.2.2 - Ambulatory Surgical Center (ASC) Facility Fee
(Rev. 10818; Issued: 05-20-21; Effective: 01-09-21; Implementation: 10-04-21)
CPT code 45378, which is used to code a diagnostic colonoscopy, is on the list of procedures
approved by Medicare for payment of an ambulatory surgical center facility under section 1833 of
the Act. CPT code 45378 is currently assigned to ASC payment group 2. Code G0105, colorectal
cancer; colonoscopy on individuals at high risk, was added to the ASC list effective for services
furnished on or after January 1, 1998. Code G0121, colorectal cancer; colonoscopy on individual
not meeting criteria for high risk, was added to the ASC list effective for services furnished on or
after July 1, 2001. Codes G0105 and G0121 are assigned to ASC payment group 2. The ASC
facility service is the same whether the procedure is a screening or a diagnostic colonoscopy. If
during the course of the screening colonoscopy performed at an ASC, a lesion or growth is detected
which results in a biopsy or removal of the growth, the appropriate diagnostic procedure classified
as a colonoscopy with biopsy or removal should be billed rather than code G0105. Effective for
services performed on or after January 1, 2007, a 25% coinsurance payment will apply for the
colorectal cancer services (G0105 and G0121).