Determining High Risk for Developing Colorectal Cancer

60.3 - Determining High Risk for Developing Colorectal Cancer (Rev. 13025, Issued: 12-23-24; Effective: 10-01-24; Implementation: 03-20-25) A. Characteristics of the High-Risk Individual An individual at high risk for developing colorectal cancer has one or more of the following: • A close relative (sibling, parent, or child) who has had colorectal cancer or an adenomatous polyp. • A family history of familial adenomatous polyposis. • A family history of hereditary nonpolyposis colorectal cancer. • A personal history of adenomatous polyps. • A personal history of colorectal cancer; or • Inflammatory bowel disease, including Crohn’s Disease, and ulcerative colitis. B. Partial List of ICD-10-CM Codes Indicating High Risk Listed below are some examples of diagnoses that meet the high-risk criteria for colorectal cancer. This is not an all-inclusive list. There may be more instances of conditions, which may be coded and could be considered high risk at the medical directors’ discretion. Partial List of diagnosis codes indicating high risk: only applicable to G0105 and G0120 (high risk colorectal cancer screening) C18.0 Malignant neoplasm of cecum C18.2 Malignant neoplasm of ascending colon C18.3 Malignant neoplasm of hepatic flexure C18.4 Malignant neoplasm of transverse colon C18.5 Malignant neoplasm of splenic flexure C18.6 Malignant neoplasm of descending colon C18.7 Malignant neoplasm of sigmoid colon C18.8 Malignant neoplasm of overlapping sites of colon C19 Malignant neoplasm of rectosigmoid junction C20 Malignant neoplasm of rectum C21.0 Malignant neoplasm of anus, unspecified C21.1 Malignant neoplasm of anal canal C21.2 Malignant neoplasm of cloacogenic zone C21.8 Malignant neoplasm of overlapping sites of rectum, anus and anal canal C49.A Gastrointestinal stromal tumor of small intestine C49.A Gastrointestinal stromal tumor of large intestine C49.A5 Gastrointestinal stromal tumor of rectum C78.5 Secondary malignant neoplasm of large intestine and rectum C7A.02 Malignant carcinoid tumor of the cecum C7A.022 Malignant carcinoid tumor of the ascending colon C7A.023 Malignant carcinoid tumor of the transverse colon C7A.024 Malignant carcinoid tumor of the descending colon C7A.025 Malignant carcinoid tumor of the sigmoid colon C7A.026 Malignant carcinoid tumor of the rectum D01.0 Carcinoma in situ of colon D01.1 Carcinoma in situ of rectosigmoid junction D01.2 Carcinoma in situ of rectum D01.3 Carcinoma in situ of anus and anal canal D12.0 Benign neoplasm of cecum D12.2 Benign neoplasm of ascending colon D12.3 Benign neoplasm of transverse colon D12.4 Benign neoplasm of descending colon D12.5 Benign neoplasm of sigmoid colon D12.7 Benign neoplasm of rectosigmoid junction D12.8 Benign neoplasm of rectum D12.9 Benign neoplasm of anus and anal canal D37.4 Neoplasm of uncertain behavior of colon D37.5 Neoplasm of uncertain behavior of rectum D37.9 Neoplasm of uncertain behavior of digestive organ, unspecified D3A.021 Benign carcinoid tumor of the cecum D3A.022 Benign carcinoid tumor of the ascending colon D3A.023 Benign carcinoid tumor of the transverse colon D3A.024 Benign carcinoid tumor of the descending colon D3A.025 Benign carcinoid tumor of the sigmoid colon D3A.026 Benign carcinoid tumor of the rectum D3A.029 Benign carcinoid tumor of the large intestine, unspecified portion K50.00 Crohn's disease of small intestine without complications K50.011 Crohn's disease of small intestine with rectal bleeding K50.012 Crohn's disease of small intestine with intestinal obstruction K50.013 Crohn's disease of small intestine with fistula K50.014 Crohn's disease of small intestine with abscess K50.018 Crohn's disease of small intestine with other complication K50.019 Crohn's disease of small intestine with unspecified complications K50.10 Crohn's disease of large intestine without complications K50.111 Crohn's disease of large intestine with rectal bleeding K50.112 Crohn's disease of large intestine with intestinal obstruction K50.113 Crohn's disease of large intestine with fistula K50.114 Crohn's disease of large intestine with abscess K50.118 Crohn's disease of large intestine with other complication K50.119 Crohn's disease of large intestine with unspecified complications K50.80 Crohn's disease of both small and large intestine without complications K50.811 Crohn's disease of both small and large intestine with rectal bleeding K50.812 Crohn's disease of both small and large intestine with intestinal obstruction K50.813 Crohn's disease of both small and large intestine with fistula K50.814 Crohn's disease of both small and large intestine with abscess K50.818 Crohn's disease of both small and large intestine with other complication K50.819 Crohn's disease of both small and large intestine with unspecified complications K50.90 Crohn's disease, unspecified, without complications K50.911 Crohn's disease, unspecified, with rectal bleeding K50.912 Crohn's disease, unspecified, with intestinal obstruction K50.913 Crohn's disease, unspecified, with fistula K50.914 Crohn's disease, unspecified, with abscess K50.918 Crohn's disease, unspecified, with other complication K50.919 Crohn's disease, unspecified, with unspecified complications K51.00 Ulcerative (chronic) pancolitis without complications K51.011 Ulcerative (chronic) pancolitis with rectal bleeding K51.012 Ulcerative (chronic) pancolitis with intestinal obstruction K51.013 Ulcerative (chronic) pancolitis with fistula K51.014 Ulcerative (chronic) pancolitis with abscess K51.018 Ulcerative (chronic) pancolitis with other complication K51.019 Ulcerative (chronic) pancolitis with unspecified complications K51.20 Ulcerative (chronic) proctitis without complications K51.211 Ulcerative (chronic) proctitis with rectal bleeding K51.212 Ulcerative (chronic) proctitis with intestinal obstruction K51.213 Ulcerative (chronic) proctitis with fistula K51.214 Ulcerative (chronic) proctitis with abscess K51.218 Ulcerative (chronic) proctitis with other complication K51.219 Ulcerative (chronic) proctitis with unspecified complications K51.30 Ulcerative (chronic) rectosigmoiditis without complications K51.311 Ulcerative (chronic) rectosigmoiditis with rectal bleeding K51.312 Ulcerative (chronic) rectosigmoiditis with intestinal obstruction K51.313 Ulcerative (chronic) rectosigmoiditis with fistula K51.314 Ulcerative (chronic) rectosigmoiditis with abscess K51.318 Ulcerative (chronic) rectosigmoiditis with other complication K51.319 Ulcerative (chronic) rectosigmoiditis with unspecified complications K51.40 Inflammatory polyps of colon without complications K51.411 Inflammatory polyps of colon with rectal bleeding K51.412 Inflammatory polyps of colon with intestinal obstruction K51.413 Inflammatory polyps of colon with fistula K51.414 Inflammatory polyps of colon with abscess K51.418 Inflammatory polyps of colon with other complication K51.419 Inflammatory polyps of colon with unspecified complications K51.50 Left sided colitis without complications K51.511 Left sided colitis with rectal bleeding K51.512 Left sided colitis with intestinal obstruction K51.513 Left sided colitis with fistula K51.514 Left sided colitis with abscess K51.518 Left sided colitis with other complication K51.519 Left sided colitis with unspecified complications K51.80 Other ulcerative colitis without complications K51.811 Other ulcerative colitis with rectal bleeding K51.812 Other ulcerative colitis with intestinal obstruction K51.813 Other ulcerative colitis with fistula K51.814 Other ulcerative colitis with abscess K51.818 Other ulcerative colitis with other complication K51.819 Other ulcerative colitis with unspecified complications K51.90 Ulcerative colitis, unspecified, without complications K51.911 Ulcerative colitis, unspecified with rectal bleeding K51.912 Ulcerative colitis, unspecified with intestinal obstruction K51.913 Ulcerative colitis, unspecified with fistula K51.914 Ulcerative colitis, unspecified with abscess K51.918 Ulcerative colitis, unspecified with other complication K51.919 Ulcerative colitis, unspecified with unspecified complications K52.1 Toxic gastroenteritis and colitis K52.89 Other specified non-infective gastroenteritis and colitis K52.9 Non-infective gastroenteritis and colitis, unspecified K57.20 Diverticulitis of large intestine with perforation and abscess without bleeding K57.21 Diverticulitis of large intestine with perforation and abscess with bleeding K57.30 Diverticulosis of large intestine without perforation or abscess without bleeding K57.31 Diverticulosis of large intestine without perforation or abscess with bleeding K57.32 Diverticulitis of large intestine without perforation or abscess without bleeding K57.33 Diverticulitis of large intestine without perforation or abscess with bleeding K57.40 Diverticulitis of both small and large intestine with perforation and abscess without bleeding K57.41 Diverticulitis of both small and large intestine with perforation and abscess with bleeding K57.50 Diverticulosis of both small and large intestine without perforation or abscess without bleeding K57.51 Diverticulosis of both small and large intestine without perforation or abscess with bleeding K57.52 Diverticulitis of both small and large intestine without perforation or abscess without bleeding K57.53 Diverticulitis of both small and large intestine without perforation or abscess with bleeding K57.80 Diverticulitis of intestine, part unspecified, with perforation and abscess without bleeding K57.81 Diverticulitis of intestine, part unspecified, with perforation and abscess with bleeding K57.90 Diverticulosis of intestine, part unspecified, without perforation or abscess without bleeding K57.91 Diverticulosis of intestine, part unspecified, without perforation or abscess with bleeding K57.92 Diverticulitis of intestine, part unspecified, without perforation or abscess without bleeding K57.93 Diverticulitis of intestine, part unspecified, without perforation or abscess with bleeding K62.0 Anal polyp K62.1 Rectal polyp K62.6 Ulcer of anus and rectum K63.3 Ulcer of intestine K63.5 Polyp of colon Z12.10 Encounter for screening for malignant neoplasm of intestinal tract, unspecified Z12.11 Encounter for screening for malignant neoplasm of colon Z12.12 Encounter for screening for malignant neoplasm of rectum Z15.09 Genetic susceptibility to other malignant neoplasm Z80.0 Family history of malignant neoplasm of digestive organs Z83.710 Family history of adenomatous and serrated polyps Z83.711 Family history of hyperplastic colon polyps Z83.718 Other family history of colon polyps Z83.719 Family history of colon polyps, unspecified Z83.72 Family history of familial adenomatous polyposis effective October 1 ,2024 Z85.038 Personal history of other malignant neoplasm of large intestine Z85.048 Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus Z86.004 Personal history of in-situ neoplasm of other and unspecified digestive organs Z86.010 Personal history of colonic polyps end date September 30, 2024 Z86.0100 Personal history of colon polyps, unspecified effective October 1 ,2024 Z86.0101 Personal history of adenomatous and serrated colon polyps effective October 1, 2024 Z86.0102 Personal history of hyperplastic colon polyps effective October 1 ,2024 Z86.0109 Personal history of other colon polyps October 1 ,2024 Applicable to G0464/81528: colorectal cancer screening; stool-based DNA and fecal occult hemoglobin (e.g., kras, ndrg4 and bmp3), as well as G0327: colorectal cancer screening; blood- based biomarker - only 1 diagnosis required Z12.12 Encounter for screening for malignant neoplasm of rectum Z12.11 Encounter for screening for malignant neoplasm of colon