Chemicals with Cumulative Noncarcinogenic Effects

Section 742 Section 742.720  Chemicals with Cumulative Noncarcinogenic Effects Appendix A, Table E lists the groups of chemicals from Appendix B, Tables A and B that have remediation objectives based on noncarcinogenic toxicity and that affect the same target organ.  If more than one chemical detected at a site affects the same target organ (i.e., has the same critical effect as defined by the RfD), the initially calculated remediation value for each chemical in the group shall be corrected for cumulative effects by one of the following two methods: a)         Calculate the weighted average using the following equations: W ave = x 1 + x 2 + x 3 +...+ x a CUO x CUO x CUO x CUO x 1 2 3 a where: W ave = Weighted Average x 1 through x a = Concentration of each individual contaminant at the location of concern. Note that, depending on the target organ/mode of action, the actual number of contaminants will range from 2 to 14. CUO x = A Tier 2 numeral remediation objective must be developed for each x a . a If the value of the weighted average calculated in accordance with the equations above is less than or equal to 1.0, then the remediation objectives are met for those chemicals. If the value of the weighted average calculated in accordance with the equations above is greater than 1.0, then additional remediation must be carried out until the level of contaminants remaining in the remediated area has a weighted average calculated in accordance with the equation above less than or equal to one. b)         Divide each individual chemical's remediation objective by the number of chemicals in that specific target organ group that were detected at the site. Each of the contaminant concentrations at the site is then compared to the remediation objectives that have been adjusted to account for this potential additivity.  For the noncarcinogenic contaminants listed in Appendix A, Table E, a respective soil remediation objective need be no lower than the respective value listed in Appendix B, Table A or B.